Neurobiological Basis of Osteopathy: Autonomic Nervous System, Interoception & Pain

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Wilfrid Jänig

Married to Dr. Ute Jänig, two sons, 1 granddaughter, 4 grandsons
1960 – 1966 Study of medicine, Universities of Tübingen, Hamburg and Heidelberg
1966 Final examinations in Medicine, University of Heidelberg, Germany
1967 Thesis “Physiology and morphology of mechanoreceptors in the skin of the central pad of the cat hindpaw”, University of Heidelberg
1971 Advanced thesis (Habilitation), University of Heidelberg

Present position
2003-now Professor emeritus of the Dept. of Physiology, University Kiel, Germany

Previous positions
1971-1973 Department of Neurobiology and Behavior of the City of New York (NYU, Prof. Eric Kandel)
1976-now Professor of Physiology, Dept. of Physiology, University Kiel, Germany
1980-1997 Visiting Professor Neurobiology Unit, Life Sciences Institute, Hebrew Univ., Jerusalem, Israel 
1981-2009 Visiting Professor Dept. of Physiology/Monash University, Baker Institute/Melbourne, Mel-bourne University, University of Queensland/Brisbane (John Mayne Prof., Dept. of Physiology & Pharmacology), Prince of Wales Medical Research Institute/Sydney
1988 Visiting scientist, Dept. of Physiology, University of Bristol, UK
1993-2002 Regular Visiting Professor (2-3 months per year), Dept. of Medicine, University of California, San Francisco; Presidential Chair of the University of California in Medicine and Dentistry (Regent´s Professor 1993-1994)
1993 Max-Planck-Prize (together with Prof. Elspeth McLachlan)
2007 Myers Fellowship, Howard Florey Institute, Melbourne, Australia 
2010 (Nov) Visiting Professor Nagoya University, Japan

Main lectures in physiology in Kiel from 1973 to now (summer and winter terms; subjects autonomic nervous system, pain, autonomic nervous system & pain, neural regulation of gastrointestinal tract and pelvic organs, autonomic nervous system and emotions)
Neurobiological mechanisms underlying manual/osteopathic medicine in Germany, Italy, Austria, Netherlands and Spain (2013-now)

Students, Meetings
Supervision of 51 students to the degree (doctoral thesis, PhD; 2 diplomas) and 12 postdoctoral fellows
Organization of 12 International Scientific Meetings 

Own published scientific work
249 original papers or reviews [2010-2018: 22], 59 textbook chapters [2010-20168: 22], 104 book chapters, editorials or comments [2010-2018: 25], 10 edited books or journal issues [2010-2018: 4], 1 book (2006 sin-gle authored)

Current and past research interests
Central & peripheral organization of the sympathetic nervous system; neural mechanisms of visceral pain: physiology and pathophysiology; neural mechanisms of neuropathic pain; sympathetic nervous system & pain; neuroendocrine & neural control of inflammation and hyperalgesia; neurobiological mechanisms under-lying manual/osteopathic medicine 

Funding of Research
German Research Foundation, Federal Ministry Education & Research, some other sources

December 2017, Kiel

Prof. Dr. Wilfrid Jänig, University of Kiel, Department of Physiology, Kiel, Germany
Autonomic Nervous System, Interoception and Pain 

14. 5. 2018 (9.00 – 13.00)
Lecture 1 General neurobiology of the autonomic nervous system: a concept 
Lecture 2 Anatomy and physiology of the peripheral autonomic nervous system

14. 5. 2018 (14.00 – 18.00)
Lecture 4 Mechanisms of nociception and pain 
Lecture 5 Referred pain and autonomic nervous system

15. 5. 2018 (9.00 – 13.00)
Lecture 6 Sympathetic nervous system & pain: physiology 
Lecture 7 Sympathetic nervous system & pain: pathophysiology
Lecture 8 The Complex Regional Pain Syndrome as a model of integration:   
                 pain,sympathetic nervous system and control by the brain


Osteopathic medicine (and other forms of manual medicine) is a form of integrative medicine that is conceptually based in its therapeutic approach on the unity of body and mind. Health and disease are biologically the result of regulation or dysregulation of the body by the brain. During diseases, that are the consequence of the dysregulation of the brain-body axis, the therapeutic aim is therefore to activate and promote the evolutionary developed mechanisms underlying health and healing. Various peripheral and central neural systems are involved in the regulation of health and healing: 
(1) Autonomic systems innervating and regulating the body tissues. 
(2) Central autonomic systems in spinal cord, brain stem and hypothalamus involved in autonomic reflexes and regulations. 
(3) Ascending afferent interoceptive systems monitoring the mechanical, thermal, metabolic, inflammatory and injured states of the body tissues and reporting them to the brain. This includes the systems of nociception and pain. 
(4) Neuroendocrine systems influencing all tissues. 
(5) Representations of the body tissues in the forebrain that integrate interoception and functions of autonomic systems (reflexes, homeostatic regulations) resulting in cortical control of the body tissues. This includes mental processes such as sensations, feelings of emotions, perceptions as well as cognition.

This integration occurs principally at all levels of organization of the systems, i.e. from the level of the body tissues to the telencephalic level. Thus, each system is not only organized in itself in a hierarchical way, but the integration between systems is also hierarchically organized. Disentangling the mechanisms underlying this integration will give us a better insight as to how these systems work at the cellular and integrative level in health and disease. To understand the integral neuronal processes is the entrance gate to understanding the mechanisms underlying the various manual therapeutic procedures used in treatment of functional diseases and dysfunctional states of the body tissues and to improve the therapies. 

The course organized by Prof. Wilfrid Jänig will concentrate on the following topics:
-     Neurobiology of the autonomic nervous system: peripheral and central organization. The enteric nervous system will only parenthetically be discussed. The topic autonomic nervous system and inflammation has been covered on the main congress.
-     Neurobiology of interoception, nociception and pain: peripheral and central mechanisms. 
-     Peripheral and central interaction and integration of nociceptive as well as other interoceptive systems on one side and autonomic systems under physiological and pathophysiological conditions on the other. 
-    The complex regional pain syndrome as a model of integration: pain, sympathetic nervous system and control by the brain. 

The teaching will be structured in an interactive way. 


Jänig, W. The integrative action of the autonomic nervous system. Neurobiology of homeostasis. Cambridge University Press, Cambridge (2006) [This book describes the neurobiology of the autonomic nervous system (in the periphery and in the brain)]
Jänig, W. Autonomic nervous system and pain. In Basbaum, A.I. Bushnell, M.C. (eds.) Science of Pain. Academic Press, San Diego, pp. 193-225 (2009)
Jänig W. The autonomic nervous system and pain: neurobiological mechanisms. In Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. edition, pp. 236-246 (2013)
Jänig, W. The autonomic nervous system. In Galizia, G., Lledo, J.-M. (eds.) Neurosciences – From Molecule to Behavior: A University Textbook. Springer-Verlag, Berlin Heidelberg, pp. 179 - 211 (2013)
Jänig, W. Neurocardiology: a neurobiologist´s perspective. J. Physiol. 594, 3955 - 3962 (2016)
Jänig, W., Levine, J.D. Autonomic, endocrine, and immune interactions in acute and chronic pain. In McMahon, S.B., Koltzenburg, M., Tracey I, Turk DC (eds.) Wall and Melzack´s Textbook of Pain, 6. edition, Elsevier Churchill Livingstone, Amsterdam Edinburgh, pp. 205-218 (2013)
Jänig, W., McLachlan, E.M. Neurobiology of the autonomic nervous system. In Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. Auflage, pp. 22 - 34 (2013)
Jänig, W., Schaumann, R., Vogt, W. (eds.) CRPS. Complex Regional Pain Syndrome. SUVACARE, Luzern (2013) [From the internet in German or French under] 
King, H.H., Jänig, W., Patterson, M.M. (eds.) The Science and Clinical Application of Manual Therapy. Churchill Livingstone Elsevier, Edinburgh (2011) [This book critically discusses the translation from the basics to application of manual therapy]
Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. edition, 2013 [At present the best and most extensive textbook on the basics, pathophysiology and clinics of the autonomic nervous system]
Robertson, R., Biaggioni, I., Burnstock, G., Low, P.A., Paton, J.F.R. (eds.) Primer of the Autonomic Nervous System. 3rd edition, Elsevier Academic Press, Oxford, (2012) [A book to look up quickly a subject]


Tipologia   Costo
Studente   € 250.00
€ 250.00 al momento dell'iscrizione
Ex AIOT   € 300.00
€ 300.00 al momento dell'iscrizione
Iscrizione standard   € 350.00
€ 350.00 al momento dell'iscrizione

Coloro che hanno intenzione di partecipare al congresso sulla Disfunzione somatica, che si svolgerà a Pescara dall'11 al 13 maggio, possono usufruire dell'offerta Congresso + Corso, iscrivendosi direttamente dal sito del congresso.

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Per gli ex studenti dell'AIOT il costo è di € 300,00 IVA inclusa

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