Prof. Dr. Wilfrid Jänig, University of Kiel, Department of Physiology, Kiel, Germany
NEUROBIOLOGICAL BASIS OF OSTEOPATHY:
Autonomic Nervous System, Interoception and Pain
14. 5. 2018 (9.00 – 13.00)
Part 1 THE AUTONOMIC NERVOUS SYSTEM
Lecture 1 General neurobiology of the autonomic nervous system: a concept
Lecture 2 Anatomy and physiology of the peripheral autonomic nervous system
14. 5. 2018 (14.00 – 18.00)
Part 2 NOCICEPTION AND PAIN
Lecture 4 Mechanisms of nociception and pain
Lecture 5 Referred pain and autonomic nervous system
15. 5. 2018 (9.00 – 13.00)
Part 3 PAIN, BODY PROTECTION AND AUTONOMIV NERVOUS SYSTEM
Lecture 6 Sympathetic nervous system & pain: physiology
Lecture 7 Sympathetic nervous system & pain: pathophysiology
Lecture 8 The Complex Regional Pain Syndrome as a model of integration:
pain,sympathetic nervous system and control by the brain
Osteopathic medicine (and other forms of manual medicine) is a form of integrative medicine that is conceptually based in its therapeutic approach on the unity of body and mind. Health and disease are biologically the result of regulation or dysregulation of the body by the brain. During diseases, that are the consequence of the dysregulation of the brain-body axis, the therapeutic aim is therefore to activate and promote the evolutionary developed mechanisms underlying health and healing. Various peripheral and central neural systems are involved in the regulation of health and healing:
(1) Autonomic systems innervating and regulating the body tissues.
(2) Central autonomic systems in spinal cord, brain stem and hypothalamus involved in autonomic reflexes and regulations.
(3) Ascending afferent interoceptive systems monitoring the mechanical, thermal, metabolic, inflammatory and injured states of the body tissues and reporting them to the brain. This includes the systems of nociception and pain.
(4) Neuroendocrine systems influencing all tissues.
(5) Representations of the body tissues in the forebrain that integrate interoception and functions of autonomic systems (reflexes, homeostatic regulations) resulting in cortical control of the body tissues. This includes mental processes such as sensations, feelings of emotions, perceptions as well as cognition.
This integration occurs principally at all levels of organization of the systems, i.e. from the level of the body tissues to the telencephalic level. Thus, each system is not only organized in itself in a hierarchical way, but the integration between systems is also hierarchically organized. Disentangling the mechanisms underlying this integration will give us a better insight as to how these systems work at the cellular and integrative level in health and disease. To understand the integral neuronal processes is the entrance gate to understanding the mechanisms underlying the various manual therapeutic procedures used in treatment of functional diseases and dysfunctional states of the body tissues and to improve the therapies.
The course organized by Prof. Wilfrid Jänig will concentrate on the following topics:
- Neurobiology of the autonomic nervous system: peripheral and central organization. The enteric nervous system will only parenthetically be discussed. The topic autonomic nervous system and inflammation has been covered on the main congress.
- Neurobiology of interoception, nociception and pain: peripheral and central mechanisms.
- Peripheral and central interaction and integration of nociceptive as well as other interoceptive systems on one side and autonomic systems under physiological and pathophysiological conditions on the other.
- The complex regional pain syndrome as a model of integration: pain, sympathetic nervous system and control by the brain.
The teaching will be structured in an interactive way.
Jänig, W. The integrative action of the autonomic nervous system. Neurobiology of homeostasis. Cambridge University Press, Cambridge (2006) [This book describes the neurobiology of the autonomic nervous system (in the periphery and in the brain)]
Jänig, W. Autonomic nervous system and pain. In Basbaum, A.I. Bushnell, M.C. (eds.) Science of Pain. Academic Press, San Diego, pp. 193-225 (2009)
Jänig W. The autonomic nervous system and pain: neurobiological mechanisms. In Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. edition, pp. 236-246 (2013)
Jänig, W. The autonomic nervous system. In Galizia, G., Lledo, J.-M. (eds.) Neurosciences – From Molecule to Behavior: A University Textbook. Springer-Verlag, Berlin Heidelberg, pp. 179 - 211 (2013)
Jänig, W. Neurocardiology: a neurobiologist´s perspective. J. Physiol. 594, 3955 - 3962 (2016)
Jänig, W., Levine, J.D. Autonomic, endocrine, and immune interactions in acute and chronic pain. In McMahon, S.B., Koltzenburg, M., Tracey I, Turk DC (eds.) Wall and Melzack´s Textbook of Pain, 6. edition, Elsevier Churchill Livingstone, Amsterdam Edinburgh, pp. 205-218 (2013)
Jänig, W., McLachlan, E.M. Neurobiology of the autonomic nervous system. In Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. Auflage, pp. 22 - 34 (2013)
Jänig, W., Schaumann, R., Vogt, W. (eds.) CRPS. Complex Regional Pain Syndrome. SUVACARE, Luzern (2013) [From the internet in German or French under http://www.SUVA.ch/waswo/2771.d]
King, H.H., Jänig, W., Patterson, M.M. (eds.) The Science and Clinical Application of Manual Therapy. Churchill Livingstone Elsevier, Edinburgh (2011) [This book critically discusses the translation from the basics to application of manual therapy]
Mathias, C.J., Bannister, R. (eds.) Autonomic Failure. Oxford University Press, Oxford, 5. edition, 2013 [At present the best and most extensive textbook on the basics, pathophysiology and clinics of the autonomic nervous system]
Robertson, R., Biaggioni, I., Burnstock, G., Low, P.A., Paton, J.F.R. (eds.) Primer of the Autonomic Nervous System. 3rd edition, Elsevier Academic Press, Oxford, (2012) [A book to look up quickly a subject]